Biochemical and mechanical regulation of extracellular matrix signaling: insights from fibronectin


Michael L. Smith
Department of Biomedical Engineering
Boston University
Presented in the Embryo Physics Course, March 5, 2014


A growing trend in tissue engineering and regenerative medicine is to view cells, matrices and whole tissues from a materials science perspective. The rationale behind this novel approach to considering biological problems is that the material properties at these different length scales both define their physical stability and also provide instructive cues. These instructive cues can maintain homeostasis in healthy tissues or drive dynamic events during development, wound healing, and disease progression. This lecture will discuss how the extracellular matrix presents these instructive cues to cells, and also how cells regulate these instructive cues through biochemical and mechanical approaches.




Education: B.S. Mechanical Engineering
University of Memphis, 1999
Ph.D. Biomedical Engineering
University of Virginia, 2004
Postdoctoral Fellow, Materials Science and Engineering
ETH Zurich, 2004-2008
Assistant Professor, Biomedical Engineering
Boston University, 2008 – Present


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